abstract：:Occupational exposure to nickel (Ni), chromium (Cr), and arsenic (As) containing compounds has been associated with lung cancer and other adverse health effects. Their carcinogenic properties may be attributable in part, to activation and/or repression of gene expression induced by changes in the DNA methylation statu...

journal_title：Toxicology and applied pharmacology

authors： Zhou X,Li Q,Arita A,Sun H,Costa M

更新日期：2009-04-01 00:00:00

abstract：:Since amitriptyline is a very frequently prescribed antidepressant drug, it is not surprising that amitriptyline toxicity is relatively common. Amitriptyline toxic systemic effects include cardiovascular, autonomous nervous, and central nervous systems. To understand the mechanisms of amitriptyline toxicity we studied...

journal_title：Toxicology and applied pharmacology

authors： Cordero MD,Moreno-Fernández AM,Gomez-Skarmeta JL,de Miguel M,Garrido-Maraver J,Oropesa-Avila M,Rodríguez-Hernández A,Navas P,Sánchez-Alcázar JA

更新日期：2009-03-15 00:00:00

abstract：:Ethambutol, an efficacious antituberculosis agent, can cause irreversible visual loss in a small but significant fraction of patients. However, the mechanism of ocular toxicity remains to be established. We previously reported that ethambutol caused severe vacuole formation in cultured retinal cells, and that the addi...

journal_title：Toxicology and applied pharmacology

authors： Chung H,Yoon YH,Hwang JJ,Cho KS,Koh JY,Kim JG

更新日期：2009-03-01 00:00:00

abstract：:Arsenic is a human carcinogen with exposure associated with cancer of the lung, skin, and bladder. Many potential mechanisms have been implicated as playing a role in the process of arsenical-induced malignancy including the perturbation of signaling pathways and aberrant epigenetic regulation. We initiated studies to...

journal_title：Toxicology and applied pharmacology

authors： Jensen TJ,Wozniak RJ,Eblin KE,Wnek SM,Gandolfi AJ,Futscher BW

更新日期：2009-02-15 00:00:00

abstract：:Female subjects have been reported to be less sensitive to the hyperthermic effects of 3,4-methylenedioxymethamine (MDMA) than males. Studies were designed to examine the cellular mechanisms involved in these sex sensitive differences. Gonadectomized female and male rats were treated with a 200 microg 100 microL(-1) o...

journal_title：Toxicology and applied pharmacology

authors： Wyeth RP,Mills EM,Ullman A,Kenaston MA,Burwell J,Sprague JE

更新日期：2009-02-15 00:00:00

abstract：:The mood stabilizing agents lithium chloride (LiCl) and sodium valproate (VPA) have recently gained interest as potential neuroprotective therapeutics. However, exploitation of these therapeutic applications is hindered by both a lack of molecular understanding of the mode of action, and a number of sub-optimal proper...

journal_title：Toxicology and applied pharmacology

authors： Plant KE,Anderson E,Simecek N,Brown R,Forster S,Spinks J,Toms N,Gibson GG,Lyon J,Plant N

更新日期：2009-02-15 00:00:00

abstract：:The aryl hydrocarbon receptor (AhR) and AhR nuclear translocator (ARNT) are transcription factors that express Per-Arnt-Sim (PAS) DNA-binding motifs and mediate the metabolism of drugs and environmental toxins in the liver. Because these transcription factors interact with other PAS genes in molecular feedback loops f...

journal_title：Toxicology and applied pharmacology

authors： Qu X,Metz RP,Porter WW,Cassone VM,Earnest DJ

更新日期：2009-02-01 00:00:00

abstract：:Infants exposed to second hand smoke (SHS) experience more problems with wheezing. This study was designed to determine if perinatal SHS exposure increases intrinsic and/or in vivo airway responsiveness to methacholine and whether potential structural/cellular alterations in the airway might explain the change in resp...

journal_title：Toxicology and applied pharmacology

authors： Joad JP,Kott KS,Bric JM,Peake JL,Pinkerton KE

更新日期：2009-02-01 00:00:00

abstract：:Chlorhexidine (CHX), widely used as antiseptic and therapeutic agent in medicine and dentistry, has a toxic effect both in vivo and in vitro. The intrinsic mechanism underlying CHX-induced cytotoxicity in eukaryotic cells is, however, still unknown. A recent study from our laboratory has suggested that CHX may induce ...

journal_title：Toxicology and applied pharmacology

authors： Faria G,Cardoso CR,Larson RE,Silva JS,Rossi MA

更新日期：2009-01-15 00:00:00

abstract：:Azole derivatives are teratogenic in rats and mice in vitro and in vivo. The postulated mechanism for the dysmorphogenetic effects is the inhibition of retinoic acid (RA)-degrading enzyme CYP26. Azole-related abnormalities are confined to structures controlled by RA, especially the neural crest cells, hindbrain, crani...

journal_title：Toxicology and applied pharmacology

authors： Di Renzo F,Corsini E,Broccia ML,Marinovich M,Galli CL,Giavini E,Menegola E

更新日期：2009-01-01 00:00:00

abstract：:Mechanisms of particulate matter (PM)-induced cardiotoxicity are not fully understood. Direct translocation of PM-associated metals, including zinc, may mediate this effect. We hypothesized that following a single intratracheal instillation (IT), zinc directly translocates outside of the lungs, reaching the heart. To ...

journal_title：Toxicology and applied pharmacology

authors： Wallenborn JG,Kovalcik KD,McGee JK,Landis MS,Kodavanti UP

更新日期：2009-01-01 00:00:00

abstract：:Oxidative damage to DNA induced by benzene is an important mechanism of its genotoxicity, which leads to chronic benzene poisoning (CBP). Therefore, genetic variation in DNA repair genes may contribute to susceptibility to CBP in the exposed population. We hypothesized that single nucleotide polymorphisms (SNPs) in hM...

journal_title：Toxicology and applied pharmacology

authors： Wu F,Zhang Z,Wan J,Gu S,Liu W,Jin X,Xia Z

更新日期：2008-12-15 00:00:00

abstract：:An infamous poison, arsenic also has been used as a drug for nearly 2400 years; in recently years, arsenic has been effective in the treatment of acute promyelocytic leukemia. Increasing evidence suggests that opposite effects of arsenic trioxide (ATO) on tumors depend on its concentrations. For this reason, the mecha...

journal_title：Toxicology and applied pharmacology

authors： Liu ZM,Huang HS

更新日期：2008-12-01 00:00:00

abstract：:As a class, the biguanides induce lactic acidosis, a hallmark of mitochondrial impairment. To assess potential mitochondrial impairment, we evaluated the effects of metformin, buformin and phenformin on: 1) viability of HepG2 cells grown in galactose, 2) respiration by isolated mitochondria, 3) metabolic poise of HepG...

journal_title：Toxicology and applied pharmacology

authors： Dykens JA,Jamieson J,Marroquin L,Nadanaciva S,Billis PA,Will Y

更新日期：2008-12-01 00:00:00

abstract：:Contact sensitization is caused by low molecular weight compounds which penetrate the skin and bind to protein. In many cases, these compounds are activated to reactive species, either by autoxidation on exposure to air or by metabolic activation in the skin. Geraniol, a widely used fragrance chemical, is considered t...

journal_title：Toxicology and applied pharmacology

authors： Hagvall L,Baron JM,Börje A,Weidolf L,Merk H,Karlberg AT

更新日期：2008-12-01 00:00:00

abstract：:During international peace-keeping missions, a diverse number of non-battle hazards may be encountered, which range from heavily polluted areas, endemic disease, toxic industrial materials, local violence, traffic, and even psychological factors. Hence, elevated risk levels from a variety of sources are encountered du...

journal_title：Toxicology and applied pharmacology

authors： Stricklin DL

更新日期：2008-11-15 00:00:00

abstract：:Benzene is used at large volumes in many different human activities. Hematotoxicity and cancer-causation as a result of benzene exposure was recognized many years ago, but the mechanisms involved remain unclear. Aberrant regulation of gap junction intercellular communication (GJIC) has been linked to both cancer induc...

journal_title：Toxicology and applied pharmacology

authors： Rivedal E,Leithe E

更新日期：2008-11-01 00:00:00

abstract：:The relationship of exposure and tissue concentration of parent chemical and metabolites over prolonged exposure is a critical issue for chronic toxicities mediated by metabolite(s) rather than parent chemical alone. This is an issue for AsV because its trivalent metabolites have unique toxicities and relatively great...

journal_title：Toxicology and applied pharmacology

authors： Kenyon EM,Hughes MF,Adair BM,Highfill JH,Crecelius EA,Clewell HJ,Yager JW

更新日期：2008-11-01 00:00:00

abstract：:Oxidative glutamate toxicity in HT22 murine hippocampal cells is a model for neuronal death by oxidative stress. We have investigated the role of proteases in HT22 cell oxidative glutamate toxicity. L-glutamate-induced toxicity was characterized by cell and nuclear shrinkage and chromatin condensation, yet occurred in...

journal_title：Toxicology and applied pharmacology

authors： Elphick LM,Hawat M,Toms NJ,Meinander A,Mikhailov A,Eriksson JE,Kass GE

更新日期：2008-10-15 00:00:00

abstract：:We have studied the role of ATP binding cassette (ABC) transporters in fetal exposure to carcinogens using 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) a known substrate for ABC transporters as a model compound. In perfusion of human term placenta, transfer of (14)C-PhIP (2 microM) through the placenta resul...

journal_title：Toxicology and applied pharmacology

authors： Myllynen P,Kummu M,Kangas T,Ilves M,Immonen E,Rysä J,Pirilä R,Lastumäki A,Vähäkangas KH

更新日期：2008-10-15 00:00:00

abstract：:Epidemiological evidence indicates that prolonged lifetime exposure to estrogen is associated with elevated breast cancer risk in women. Oxidative stress and estrogen receptor-associated proliferative changes are suggested to play important roles in estrogen-induced breast carcinogenesis. In the present study, we inve...

journal_title：Toxicology and applied pharmacology

authors： Mense SM,Remotti F,Bhan A,Singh B,El-Tamer M,Hei TK,Bhat HK

更新日期：2008-10-01 00:00:00

abstract：:Often, chemotherapy by doxorubicin (Adriamycin) is limited due to life threatening cardiotoxicity in patients during and posttherapy. Recently, we have shown that moderate diet restriction remarkably protects against doxorubicin-induced cardiotoxicity. This cardioprotection is accompanied by decreased cardiac oxidativ...

journal_title：Toxicology and applied pharmacology

authors： Mitra MS,Donthamsetty S,White B,Mehendale HM

更新日期：2008-09-15 00:00:00

abstract：:Juvenile rats have been reported to be more sensitive to the acute neurotoxic effects of the pyrethroid deltamethrin than adults. While toxicokinetic differences between juveniles and adults are documented, toxicodynamic differences have not been examined. Voltage-gated sodium channels, the primary targets of pyrethro...

journal_title：Toxicology and applied pharmacology

authors： Meacham CA,Brodfuehrer PD,Watkins JA,Shafer TJ

更新日期：2008-09-15 00:00:00

abstract：:The iron chelate, ferric nitrilotriacetate (FeNTA), induces acute proximal tubular necrosis as a consequence of lipid peroxidation and oxidative tissue damage. Chronic exposure of FeNTA leads to a high incidence of renal adenocarcinomas in rodents. NF-E2-related factor 2 (Nrf2) is a transcription factor that is activa...

journal_title：Toxicology and applied pharmacology

authors： Tanaka Y,Aleksunes LM,Goedken MJ,Chen C,Reisman SA,Manautou JE,Klaassen CD

更新日期：2008-09-15 00:00:00

abstract：:To examine the magnitude of human variability across the entire transcriptome after chemical challenge, we profiled gene expression responses to three different prototypic chemical inducers in primary human hepatocyte cultures from ten independent donors. Correlation between basal expression in any two hepatocyte dono...

journal_title：Toxicology and applied pharmacology

authors： Goyak KM,Johnson MC,Strom SC,Omiecinski CJ

更新日期：2008-09-01 00:00:00

abstract：:Epidemiological studies indicate that low levels of polychlorinated biphenyl (PCB) exposure can adversely affect neurocognitive development. In animal models, perturbations in calcium signaling, neurotransmitters, and thyroid hormones have been postulated as potential mechanisms for PCB-induced developmental neurotoxi...

journal_title：Toxicology and applied pharmacology

authors： Royland JE,Kodavanti PR

更新日期：2008-09-01 00:00:00

abstract：:Diesel exhaust particles (DEPs) cause many adverse health problems, and reports indicate increased risk of breast cancer in men and women through exposure to gasoline and vehicle exhaust. However, DEPs include vast numbers of compounds, and the specific compound(s) responsible for these actions are not clear. We recen...

journal_title：Toxicology and applied pharmacology

authors： Furuta C,Suzuki AK,Watanabe G,Li C,Taneda S,Taya K

更新日期：2008-08-01 00:00:00

abstract：:Drinking water contaminated with arsenic, a human carcinogen, is a worldwide health issue. An understanding of cellular signaling events in response to arsenic exposure and rational designing of strategies to reduce arsenic damages by modulating signaling events are important to fight against arsenic-induced diseases....

journal_title：Toxicology and applied pharmacology

authors： Wang XJ,Sun Z,Chen W,Li Y,Villeneuve NF,Zhang DD

更新日期：2008-08-01 00:00:00

abstract：:Benzo[a]pyrene (BaP), a polyaromatic hydrocarbon produced by the combustion of cigarettes and coke ovens, is a known procarcinogen. BaP activates the aryl hydrocarbon receptor (AhR) and induces the expression of a battery of genes, including CYP1A1, which metabolize BaP to toxic compounds. The possible role of CYP1 en...

journal_title：Toxicology and applied pharmacology

authors： Endo K,Uno S,Seki T,Ariga T,Kusumi Y,Mitsumata M,Yamada S,Makishima M

更新日期：2008-07-15 00:00:00

abstract：:Despite the depth of knowledge concerning the pathogenesis of acute myeloblastic leukemia (AML), long-term survival remains unresolved. Therefore, new agents that act more selectively and more potently are required. In that line, we have recently characterized a novel diterpene ester, called 3-hydrogenkwadaphnin (3-HK...

journal_title：Toxicology and applied pharmacology

authors： Moosavi MA,Yazdanparast R

更新日期：2008-07-01 00:00:00

abstract：:Brominated flame retardants (BFRs) are present in many consumer products ranging from fabrics to plastics and electronics. Wide use of flame retardants can pose an environmental hazard and it is of interest to determine the mechanism of their toxicity. Of all the BFRs, 3,3',5,5'-tetrabromobisphenol A (TBBPA) is produc...

journal_title：Toxicology and applied pharmacology

authors： Chignell CF,Han SK,Mouithys-Mickalad A,Sik RH,Stadler K,Kadiiska MB

更新日期：2008-07-01 00:00:00

abstract：:The aims of this study were to investigate whether several histamine receptor agonists and antagonists are subjected to receptor-independent ion trapping into acidic organelles, and whether this sequestration influences their pharmacological or toxicological properties. Vacuolar (V)-ATPase-dependent intracellular sequ...

journal_title：Toxicology and applied pharmacology

authors： Morissette G,Lodge R,Bouthillier J,Marceau F

更新日期：2008-06-15 00:00:00

abstract：:Dithiocarbamates have a wide spectrum of applications in industry, agriculture and medicine with new applications being actively investigated. One adverse effect of dithiocarbamates is the neurotoxicity observed in humans and experimental animals. Results from previous studies have suggested that dithiocarbamates elev...

journal_title：Toxicology and applied pharmacology

authors： Viquez OM,Valentine HL,Amarnath K,Milatovic D,Valentine WM

更新日期：2008-05-15 00:00:00

abstract：:Due to its unique physicochemical and optical properties, C60 has raised interest in commercialization for a variety of products. While several reports have determined this nanomaterial to act as a powerful antioxidant, many other studies have demonstrated a strong oxidative potential through photoactivation. To direc...

journal_title：Toxicology and applied pharmacology

authors： Usenko CY,Harper SL,Tanguay RL

更新日期：2008-05-15 00:00:00

abstract：:Phytochemicals show promise as potential chemopreventive or chemotherapeutic agents against various cancers. Here we report the chemotherapeutic effects of berberine, a phytochemical, on human prostate cancer cells. The treatment of human prostate cancer cells (PC-3) with berberine induced dose-dependent apoptosis but...

journal_title：Toxicology and applied pharmacology

authors： Meeran SM,Katiyar S,Katiyar SK

更新日期：2008-05-15 00:00:00

abstract：:Nutrient availability is one of the major non-genetic factors determining embryonic growth and larval or fetal size. Due to the high human consumption of blood lipid regulators, fibrates have recently been reported as pollutants in rivers. Our study investigated the developmental toxicity of fibrates in zebrafish. Tre...

journal_title：Toxicology and applied pharmacology

authors： Raldúa D,André M,Babin PJ

更新日期：2008-05-01 00:00:00

abstract：:Previous experiments showed that treatment of mice and rats with thioacetamide (TAA) induced liver cell damage, fibrosis and/or cirrhosis, associated with increased oxidative stress and activation of hepatic stellate cells. Some experiments suggest that CYP2E1 may be involved in the metabolic activation of TAA. Howeve...

journal_title：Toxicology and applied pharmacology

authors： Kang JS,Wanibuchi H,Morimura K,Wongpoomchai R,Chusiri Y,Gonzalez FJ,Fukushima S

更新日期：2008-05-01 00:00:00

abstract：:Interference of exogenous chemicals with the aromatase enzyme can be useful as a tool to identify chemicals that could act either chemopreventive for hormone-dependent cancer or adverse endocrine disruptive. Aromatase is the key enzyme in the biosynthesis of steroids, as it converts androgens to estrogens. Certain fla...

journal_title：Toxicology and applied pharmacology

authors： van Meeuwen JA,Nijmeijer S,Mutarapat T,Ruchirawat S,de Jong PC,Piersma AH,van den Berg M

更新日期：2008-05-01 00:00:00

abstract：:Benzene is a known human leukemogen, but its role as an in utero leukemogen remains controversial. Epidemiological studies have correlated parental exposure to benzene with an increased incidence of childhood leukemias. We hypothesize that in utero exposure to benzene may cause leukemogenesis by affecting the embryoni...

journal_title：Toxicology and applied pharmacology

authors： Wan J,Winn LM

更新日期：2008-05-01 00:00:00

abstract：:Molecule-targeted therapies like those against the epidermal growth factor receptor (EGFR) are becoming widely used in the oncology clinic. With improvements in treatment efficacy, many cancers are being treated as chronic diseases, with patients having prolonged exposure to several therapies that were previously only...

journal_title：Toxicology and applied pharmacology

authors： Barrick CJ,Yu M,Chao HH,Threadgill DW

更新日期：2008-05-01 00:00:00